Dept. of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai , India
” Amyloid Fibrils: Certain Molecular Level Structural Insights with Solid-State Nuclear Magnetic Resonance. “
Abstract:
Ab peptides are interesting models for investigating different aspects of amyloid aggregation. On the basis of amyloid cascade hypothesis, which has dominated amyloid disease research for the past two decades, the main therapeutic strategies have aimed either to prevent the aggregation of Ab, or to remove toxic oligomeric and fibrillar species of Ab. Since Ab is ordinarily produced in the brain, and there is no proof that Ab overproduction underlies sporadic AD, the pursuit of former strategy demands a thorough understanding of all the neurochemical factors that initiate Aβ deposition in brain….
Einladung Polymer- und Soft-Matter-Seminar 23.07.2013 Prof. PK Madhu
