17.15 Uhr im Seminarraum 1.27 Von-Danckelmann-Platz 4, 06120 Halle
(Computational Biochemistry Group ICS-6: Structural Biochemistry, Forschungzentrum Jülich)
“Thermodynamics and kinetics of amyloid aggregation from atomistic simulations”
Abstract:
A major cause for cellular toxicity involved in the onset of several neurodegenerative diseases is the aberrant aggregation of proteins into oligomers and eventually fibrils. In the case of Alzheimer’s disease, the main aggregating protein is the amyloid β-protein with two main alloforms of 40 (Aβ40) and 42 (Aβ42) amino acids. Numerous experimental studies have shown that…
