Institute of Organic Chemistry, University of Würzburg.
Felix-Bloch-Vorlesung der GDCh:
“Taking up the chase with NMR Spectroscopy – From structural insights into solid drug-polymer formulations to their fate in biorelevant media.”
Abstract:
Despite the large number of publications related to drug delivery, recent (critical) comments identified a gap between academic research and benefit to the patient requiring multidisciplinary joint efforts. Through solid-state NMR spectroscopy complemented by quantum chemical calculations, insight into the conformation of guests within copolymer micelles and key intermolecular interactions can be gained. This information enables to hypothesize loading mechanisms, explain pharmaceutically relevant dissolution rates, and derive ideas for improved polymeric carrier materials. […]